Does particle disease really exist?
نویسنده
چکیده
Sir,—The hypothesis of wear particles causing foreign-body reaction, periprosthetic osteolysis and eventually prosthetic loosening was already put forward in the 1970s (Brinkmann and Heilmann 1974, Willert et al. 1974). The term cement disease was coined in the 1980s (Jones and Hungerford 1987), generalized to particle disease in the 1990s (Harris 1994), and wear particles are still widely considered to cause prosthetic loosening by a foreign-body reaction, i.e. through a complex series of infl ammatory responses to the wear particles. However, the results of some studies contradict this hypothesis of wear-particle-induced loosening. Hence, it seems justifi ed to review the evidence and the counter-evidence for this hypothesis.
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